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Editorial: Vaporization is vaporization, but not at any cost…

The paper by Ghobrial et al. [1] confirms that bipolar electrocautery vaporization is more cost‐effective than GreenLight Laser vaporization, as the two techniques are equally effective but GreenLight vaporization is more costly in the smaller prostates being studied.

Underpinning the analysis was a well‐conducted randomized controlled trial, showing equivalent peri‐operative and postoperative measures with the two procedures and no difference in the primary endpoint of IPSS reduction at 2 years. The two techniques were performed in a similar manner and were equally efficient and safe as expected.

Philosophically, the clinical results are both unsurprising and expected, and confirm the long‐held belief that the energy source employed for vaporization and, for that matter, enucleation, is of secondary concern compared to the skill and dedication of the operator. The technique in either case should result in comparable efficacy, leaving cost‐effectiveness to be an important way to help both urologists and administrators discriminate between them.

Although the costs are not necessarily going to be comparable with those in other jurisdictions, this will apply equally to both treatments and this study therefore represents an excellent attempt to cost both procedures, removing equivalent costs. Importantly, this assessment included the costs of both readmissions and interventions over the full 24‐month period. This captures the bulk of the important complications after these types of procedures and adds to the validity of the findings.

The big difference between the costs of the two treatments being studied is, of course, ‘capital equipment including maintenance’. The single‐use fibre model rather than the cost of the machine has been the mainstay for the profitability of laser companies since the inception of laser prostatectomy. The maintenance contract has been a further cost, which is always underestimated. Reusability of the laser fibres is one way of diminishing per‐procedure costs, but is only consistently possible for Holmium end‐fire fibres [2]. The fact that the authors estimate of these costs was a ‘case share in 5‐year budget plan’ also suggests that the true cost of the use of the GreenLight laser is underestimated.

With the burgeoning number of new techniques and technologies for the treatment of BPH emerging, and new treatment paradigms being proposed, let alone the increasingly negative focus on medical waste [3] and the increasing use of single‐use disposable handpieces/tubing/drapes/fibres, articles such as this are timely. A standardized methodology for assessing the cost‐effectiveness of treatments for BPH is needed and should be an essential part of pivotal studies and therefore the regulatory approval processes.

by Peter Gilling

 

References

  1. Ghobrial FKShoma AElshal AM et al. A randomized trial comparing bipolar transurethral vaporization of the prostate with GreenLight laser (xps‐180watt) photoselective vaporization of the prostate for treatment of small to moderate benign prostatic obstruction: outcomes after 2 years. BJU Int2020124144– 52
  2. Fraundorfer MRGilling PJKennett KMDunton NGHolmium laser resection of the prostate is more cost effective than transurethral resection of the prostate: results of a randomized prospective study. Urology 200157454– 8
  3. Rose EDModlin DMCiampa MLMangieri CWFaler BJBandera BCEvaluation of operative waste in a military medical center: analysis of operating room cost and waste during surgical cases. Am Surg. 201985717– 20

 

Residents’ podcast: A randomized trial comparing bipolar TUVP with GreenLight laser PVP for treatment of small to moderate benign prostatic obstruction: outcomes after 2 years

Maria Uloko is a Urology Resident at the University of Minnesota Hospital.

A randomized trial comparing bipolar transurethral vaporization of the prostate with GreenLight laser (xps‐180watt) photoselective vaporization of the prostate for treatment of small to moderate benign prostatic obstruction: outcomes after 2 years

Read the full article

Abstract

Objective

To test the non‐inferiority of bipolar transurethral vaporization of the prostate (TUVP) compared to GreenLight laser (GL) photoselective vaporization of the prostate (PVP) for reduction of benign prostatic hyperplasia‐related lower urinary tract symptoms in a randomized trial.

Methods

Eligible patients with prostate volumes of 30–80 mL were randomly allocated to GL‐PVP (n = 58) or bipolar TUVP (n = 61). Non‐inferiority of symptom score (International Prostate Symptom Score [IPSS]) at 24 months was evaluated. All peri‐operative variables were recorded and compared. Urinary (IPSS, maximum urinary flow rate and post‐void residual urine volume) and sexual (International Index of Erectile Function‐15) outcome measures were evaluated at 1, 4, 12 and 24 months. Need for retreatment and complications, change in PSA level and health resources‐related costs of both procedures were recorded and compared.

Results

Baseline and peri‐operative variables were similar in the two groups. At 1, 4, 12 and 24 months, 117, 116, 99 and 96 patients, respectively, were evaluable. Regarding urinary outcome measures, there was no significant difference between the groups. The mean ± sd IPSS at 1 and 2 years was 7.1 ± 3 and 7.9 ± 2.9 (P = 0.8), respectively, after GL‐PVP and 6.3 ± 3.1 and 7.2 ± 2.8, respectively, after bipolar TUVP (P = 0.31). At 24 months, the mean difference in IPSS was 0.7 (95% confidence interval −0.6 to 2.3; P = 0.6). The median (range) postoperative PSA reduction was 64.7 (25–99)% and 65.9 (50–99)% (P = 0.006) after GL‐PVP, and 32.1 (28.6–89.7)% and 39.3 (68.8–90.5)% (P = 0.005) after bipolar TUVP, at 1 and 2 years, respectively. After 2 years, retreatment for recurrent bladder outlet obstruction was reported in eight (13.8%) and 10 (16.4%) patients in the GL‐PVP and bipolar TUVP groups, respectively (P = 0.8). The mean estimated cost per bipolar TUVP procedure was significantly lower than per GL‐PVP procedure after 24 months (P = 0.01).

Conclusions

In terms of symptom control, bipolar TUVP was not inferior to GL‐PVP at 2 years. Durability of the outcome needs to be tracked. The greater cost of GL‐PVP compared with bipolar TUVP is an important concern.

 
More podcasts

BJUI Podcasts are available on iTunes: https://itunes.apple.com/gb/podcast/bju-international/id1309570262

 

 

2019 Reviewers

Thank you to our 2019 Reviewers

We would particularly like to thank the following individuals who are the top reviewers for the journal in 2019, all with >10 reviews:

 

Andrew Elders Alexander Cole
Nathan Lawrentschuk Kelly Stratton
Janet Baack Kukreja Stacy Loeb
Robert H. Thompson Hashim Ahmed

 

We are extremely grateful to all our reviewers for their time and hard work

Aastha Abboudi, Hamid Abdollah, Firas Abern, Michael
Abufaraj, Mohammad Adam, Andy Adolfsson, Jan Adshead, James
Ahlawat, Rajesh Ahmed, Aamir Ahmed, Kamran Aho, Tev
Al Jaafari, Feras Albersen, Maarten Albertsen, Peter Albuquerque, Emanuel
Ambrosio, Maria Amoroso, Peter Amparore, Daniele Anastasiadis, Anastasios
Anderson, Paul Andersson, Karl-Erik Andriole, Gerald Anele, Uzoma
Antonelli, Jodi Apostolidis, Apostolos Arora, Sohrab Asplin, John
AUDENET, François Auvinen, Anssi Aydin, Abdullatif Baard, Joyce
Bachmann, Lucas Ball, Mark Barber, Neil Barod, Ravi
Basak, Ram Becerra, Maria F. Beckmann, Kerri Bedke, Jens
Beiles, Charles Barry Berger, Lorenz Bertolo, Riccardo Beyer, Burkhard
Beyer, Katharina Bhandari, Mahendra Bianchi, Lorenzo Bishop, Conrad
Bivalacqua, Trinity Blaivas, Jerry Blecher, Gideon Blok, Bertil
Blute, Michael Bodie, Joshua Bogaert, Guy Bokhorst, Leonard
Bolgeri, Marco Bolton, Damien Boorjian, Stephen Borofsky, Michael S.
Borza, Tudor Bouchier-Hayes, David Bowers, Aaron BOZKURT, Ibrahim
Braga, Luis Bratt, Ola Bravi, Carlo Andrea Breau, Rodney
Brembilla, Giorgio Breyer, Benjamin Brown, Christian Brown, Matthew
Buckley, Jill Budäus, Lars Bujons, Anna Bultitude, Matthew
Burger, Maximilian Buscarini, Maurizio Cahill, Declan Calvert, Robert
Campi, Riccardo Canales, Benjamin K. Canda, Abdullah Cantiello, Francesco
Capece, Marco Capogrosso, Paolo Carillo, Mauro CARLO, BUONERBA
Castellani, Daniele Castiglione, Fabio Cathcart, Paul Cayan, Selahittin
Celia, Antonio Celik, Serdar Cellek, Selim Challacombe, Ben
Chandak, Pankaj Chandra, Ashish Chandrasekar, Thenappan Chang, Peter
Chapin, Brian Chapple, Christopher Chartier-Kastler, Emmanuel Checcucci, Enrico
Chee, Justin Chemasle, Christophe Chen, Jian Chen, Qi
Chen, Ronald Chew, Ben Chi, Thomas Chin, Joseph
Chin, Peter Chiong, Edmund Chiriaco, Giovanni Cho, Kang Su
Cho, Min Chul Choi, Haesun Choi, Seungtaek Choong, Simon
Christopher, Andrew Chudek, Jerzy Chung, Jinsoo Clark, Peter
Cocci, Andrea Collins, Justin Connell, Shea Connolly, Stephen
Cook, Gary Costello, Anthony Cranston, David Crawford, David
Cresswell, Joanne Crestani, Alessandro Cruz, Célia Cruz, Francisco
Culig, Zoran Cumberbatch, Marcus Cutress, Mark Dahm, Philipp
Dall’Era, Marc Damber, Jan-Erik Dangle, Pankaj Danilack, V. A.
Danuser, Hansjoerg Das, Akhil DasGupta, Ranan Davis, John
Davis, Niall de Castro Abreu, Andre Luis De La Rosette, Jean De Luca, Stefano
De Nunzio, Cosimo Del Popolo, Giulio Delahunt, Brett Dell’Oglio, Paolo
Denstedt, John Desai, Janak Desai, Mahesh Deshpande, Aniruddh
Di Muzio, Nadia Ding, Maylynn Dinkelman-Smit, M. Dizman, Nazli
Djordjevic, Miroslav Dmochowski, Roger Downing, Amy Dragos, Laurian
Dudderidge, Tim Dukic, Ivo Dundee, Philip Eardley, Ian
Eberli, Daniel Eden, Christopher Efstathiou, Jason Ehdaie, Behfar
Eisner, Brian El-Ghoneimi, Alaa Elhage, Oussama Elliott, Sean
Elshal, Ahmed Elsheikh, Mohamed Elterman, Dean Emberton, Mark
Emiliani, Esteban Engeler, Daniel Enting, Deborah Epstein, Jonathan
Erci, Behice Everaert, Karel Everaerts, Wouter Fajkovic, Harun
Falagario, Ugo Farhat, Walid Ferriero, MariaConsiglia Ferro, Matteo
Ficarra, Vincenzo Figg, William Filson, Christopher Finch, William
Fiorini, Paolo Fisch, Margit Fisher, Rebecca Fishman, Mayer
Fleshner, Neil Fletcher, Sean Fok, Cynthia Fong, Eva
Foo, Keong Tatt Foreman, Darren Fraundorfer, Mark Friberg, Anne Sofie
Froehner, Michael Frydenberg, Mark Gacci, Mauro Gadzhiev, Nariman
Gakis, Georgios Galfano, Antonio Ghagane, Shridhar C. Ghani, Khurshid
Ghose, Amit Giannantoni, Antonella Giannarini, Gianluca Giganti, Francesco
Gild, Philipp Gill, Inderbir Gilling, Peter Giusti, Guido
Gokce, Mehmet Ilker Goldfarb, David Goldman, Howard Gontero, Paulo
Goossen, Hans Gordon, Stephen Gore, John Gorin, Michael
Graefen, Markus Gray, Elin Greenwell, Tamsin Gregg, Justin
Grey, Alistair Grey, Benjamin Gross, Andreas Gross, Martin
Grummet, Jeremy Gu, Meng Gulati, Roman Gundeti, Mohan
Gupta, Mohit Gupta, Nikhil K. Guru, Khurshid Guruli, Georgi
Habous, Mohamad Hackett, Geoff Hadjipavlou, Marios Hahn, Andrew
Hamid, Rizwan Hamidi, Nurullah Han, Bangmin Han, Misop
Hanna, Nawar Hanno, Philip Hart, Nicolas Hasan, Mudhar
Häuser, Lorine Heesakkers, John Hegarty, Paul Heidenreich, Axel
Heller, Nick Hemal, Ashok Hennessey, Derek Herlemann, Annika
Hevia, Mateo Hindley, Richard Hsi, Ryan S. Huang, Jay
Hubscher, Charles Huddart, Robert Hughes, Francis Hughes, Simon
Hung, Andrew Hwang, Eu Chang Ilg, Marcus Ingham, Matthew
Irtan, Sabine Irving, Stuart Jack, Greg Jeldres, Claudio
Jeong, Chang Wook Jiwane, Ashish Johnson, Mark Joseph, Jean
Joshi, Pankaj Jung, Jae Hung Kadıoğlu, Ateş Kahokehr, Arman
Kalapara, Arveen Kalejaiye, Ayo Kamat, Ashish Kapoor, Jada
Karakiewicz, Pierre Karam, Jose Karunanithy, Narayan Kasivisvanathan, Veeru
Kavoussi, Louis Kaynar, Mehmet Keeley, Frank Kemal, Sarica
Khan, Azhar Khochikar, Makarand Khoubehi, Bijan Kim, Isaac
Kim, Jae Heon Kim, Simon King, Martin Kirby, Michael
Kirkman, Maggie Kirsch, Andrew Kirschner-Hermanns, Ruth Kishan, Amar
Kitta, Takeya Klaassen, Zachary Klatte, Tobias Knudsen, Bodo
Koch, Michael Kockelbergh, Roger Konety, Badrinath Koo, Kevin
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Krasnow, Ross Krauss, Daniel J. Krimphove, Marieke Kryvenko, Oleksandr
Kulkarni, Ravi Kulkarni, Sanjay Kumar, Sunil Kundu, Bibhas
Kuo, Hann-Chorng Kusaka, M. Kutlu, Omer Kwon, Ohseong
Lam, Wayne Lamb, Alastair Lamb, Benjamin Lancia, Andrea
Landman, Jaime Lane, Giulia Lange, Dirk Laniado, Marc
Larcher, Alessandro Lau, Adrian Laudone, Vincent Lavallée, Luke
Lawrenson, Ross Lee, Byron Lee, David Lee, Jason Y.
Lee, Jongsoo Lee, Won Ki Lee, Young Joon Leitner, Lorenz
Lerner, Lori Lestingi, Jean Leveridge  , Michael Levine, Larry
Li, Jianxing Li, Roger LIATSIKOS, EVANGELOS Liauw, Stanley
Lieske, John Lin, Guiting Lingeman, James Lipkin, Michael
Lipshultz, Larry Liu, Hongbin Løgager, Vibeke López, Pedro José
Lotan, Tamara Ma, Runzhuo Madersbacher, Stephan Mahal, Brandon
Majima, Tsuyoshi Makanjuola, Jonathan Malde, Sachin Mamode, Nizam
Mandel, Philipp Manecksha, Rustom Manfredi, Matteo Marchioni, Michele
Mark, Stephen Marks, Leonard Martin, Richard Martinez-Salamanca, Juan
Martini, Alberto Masson-Lecomte, Alexandra Matsuda, Tadashi Mattei, Agostino
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McNeill, S McNicholas, Thomas Mehan, Nicholas Mehnert, Ulrich
Menichetti, Julia Meyer, Christian Milenkovic, Uros Minhas, Suks
Mir, Maria Misrai, Vincent Mizokami, Atsushi Mizuno, Kentaro
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Monga, Manoj Montanari, Emanuele Montorsi, Francesco Moochhala, Shabbir
Moon, Daniel Moore, Caroline Moran, Diarmaid Morel Journel, Nicolas
MORETTI, KIM Morey, Allen F. Moschini, Marco Mossanen, Matthew
Mostafid, Hugh MOURMOURIS, PANAGIOTIS Mout, Lisanne Muir, Gordon
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Nazzani, Sebastiano Netsch, Christopher Nguyen, David-Dan Nicolai, Nicola
Norberto, Bernardo Novara, Giacomo Nunes-Silva, Igor O’Brien, Timothy
Odisho, Anobel Ogden, Chris Ohlander, Samuel O’Kelly, Fardod
Olsburgh, Jonathon Onem, Kadir Osmonov, Daniar Ost, Piet
Ozyavuz, Rasin Paciotti, Marco Pais, Jr., Vernon Pais, Vernon
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Pannek, Jürgen Pariser, Joseph Patel, Hiten Patel, Nishant
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Paul, Asit Pavlovich, Christian Pearce, Ian Pearce, Shane
Pearle, Margaret Penson, David Peters, Kenneth Pierorazio, Phillip
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Porten, Sima Porter, James Portis, Andrew Potretzke, Aaron
Preminger, Glenn Presicce, Fabrizio Preston, Mark Purohit, Rajveer
Radtke, Jan Philipp Rai, Bhavan Rais-Bahrami, Soroush Raison, Nicholas
Ralph, David Ramakrishnan, Venkat Ramani, Vijay Ramasamy, Ranjith
Ramaswamy, Ashwin Ramón de Fata, Fernando Ranasinghe, Weranja Randhawa, Karen
Rane, Abhay Rashid, Prem Rassweiler, Jens Rastinehad, Ardeshir
Ratan, Hari Reddy, Sumeet Rees, Geraint Rees, Rowland
Reese, Stephen Reiter, Robert Resorlu, Berkan Rha, Koon Ho
Rink, Michael Rivera, Marcelino Riza Kural, Ali Robert, Grégoire
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Rogers, Alistair Rogers, Craig Roghmann, Florian Roobol, Monique
Rose, Brent Roseman, John Ross, Ashley Roth, Beat
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Russo, Giorgio Ivan Sabnis, Ravindra Sade, Recep Sahai, Arun
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Samaratunga, Hemamali Sammon, Jesse Samnakay, Naeem Samplaski, Mary
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Schutzer, Matthew Sedigh, Omid Segaran, Surayne Seisen, Thomas
Sellitti, Donald Semins, Michelle Sengupta, Shomik Sethia, Krishna
Sfakianos, John Shao, Yi Shaw, Greg Shigemura, Katsumi
Shiranov, Kirill Shrotri, Nitin Shukla, Aseem Silverman, Joshua
Singh, Avinash Siva, Shankar Skarecky, Douglas Skolarus, Ted
Smith, Angela Smith, Arthur Smith, Thomas Soares, Ricardo
Soderberg, Leah Sodha, Hiren Soeterik, Timo Sofer, Mario
Sofikitis, Nikolaos Sokoll, Lori Somani, Bhaskar Sonpavde, Guru
Sood, Akshay Soomro, Naeem Sooriakumaran, Prasanna Speakman, Mark
Spiess, Phillippe Spratt, Daniel Srinivasan, Arun Stai, Bethany
Stamatakis, Lambros Standring, Susan Stattin, Pär Stebbing, Justin
Stephan, Carsten Stewart, Grant Stish, Bradley Stoianovici, Dan
Stone, Nelson Stricker, Phillip Stroman, Luke Studd, Rodney
Suardi, Nazareno Subudhi, Sumit Sujenthiran, Arunan Sundi, Debasish
Sur, Roger Swann, Ray Tae, Bum Sik Tailly, Thomas
Takagi, Toshio Tan, Wei Shen Tay, Kae Jack Taylor, Claire
Te, Alexis Teichman, Joel Teoh, Jeremy Tewari, Ash
Thalmann, George Thimmegowda, Manohar Thomas, Kay Thurairaja, Ramesh
Tikkinen, Kari Tilki, Derya Torremade Barreda, Josep Tosoian, Jeffrey
Tran, Maxine Trinh, Quoc-Dien Trinh, Vincent Tsivian, Matvey
Tu, Shi-Ming Tubaro, Andrea Tully, Karl Turajlic, Samra
Turney, Ben Ukimura, Osamu Urkmez, Ahmet Uruc, Fatih
Uzzo, Robert van den Bergh, Roderick Van der Aa, Frank Van der Kwast, Theodorus
Van Hemelrijck, Mieke van Kerrebroeck, Philip van Renterghem, Koenraad van Rij, Simon
Vanni, Alex Vasdev, Nikhil Vasdev, Nikhil Vela, Ian
Verma, Hema Vernooij, Robin Vicentini, Fabio C Villers, Arnauld
Vivian, Justin Wagenlehner, Florian Wallis, Christopher Walsh, Anna
Walsh, Patrick Walton, Thomas Wang, Shaogang Wang, Ye
Ward, John Warner, Jonathan Watanabe, Hiroki Watkin, Nick
Watson, William Weight, Christopher Weizer, Alon Welk, Blayne
Westney, Ouida Weston, Robin White, Jared Williams, Michael
Williams, Stephen Willis, Susan Winkle, David Wiseman, Oliver
Withington, John Wong, Kathie Wong, Lih-Ming Woo, Henry
Woo, Sungmin Wood, Dan Woon, Dixon Teck Sing Wright, Anne
Wu, Wenqi Wyant, Cole Wysock, James Xu, Kewei
Xylinas, Evanguelos Yafi, Faysal Yang, Dong-Rong Yap, Tet
Yassaie, Omid Yaxley, John Ye, Dingwei Yoshimura, Naoki
Zamboglou, Constantinos Zamboni, Stefania Zargar, Homi Zeng, Guohua
Zhao, Lee Zhu, Gang Zhu, Xiaoye Zondervan, Patricia
Zorn, Kevin

 

 

We look forward to working with you again in 2020.

 

Article of the week: Likert vs PI‐RADS v2: a comparison of two radiological scoring systems for detection of clinically significant PCa

Every week, the Editor-in-Chief selects an Article of the Week from the current issue of BJUI. The abstract is reproduced below and you can click on the button to read the full article, which is freely available to all readers for at least 30 days from the time of this post.

In addition to the article itself, there is an editorial written by a prominent member of the urological community and a video prepared by the authors; we invite you to use the comment tools at the bottom of each post to join the conversation. 

If you only have time to read one article this week, we recommend this one. 

Likert vs PI‐RADS v2: a comparison of two radiological scoring systems for detection of clinically significant prostate cancer

Christopher C. Khoo*, David Eldred-Evans*, Max Peters, Mariana Bertoncelli Tanaka*, Mohamed Noureldin*, Saiful Miah*, Taimur Shah*, Martin J. Connor*, Deepika Reddy*, Martin Clark§, Amish Lakhani§, Andrea Rockall§, Feargus Hosking-Jervis*, Emma Cullen*, Manit Arya*, David Hrouda, Hasan Qazi, Mathias Winkler*, Henry Tam§ and Hashim U. Ahmed*

*Imperial Prostate, Division of Surgery, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Imperial Urology, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London, UK, Department of Radiotherapy, University Medical Centre, Utrecht, The Netherlands, §Department of Radiology, Charing Cross Hospital, Imperial College Healthcare NHS Trust and Department of Urology, St. George’s Hospital, St. George’s Healthcare NHS Trust, London, UK

Read the full article

Abstract

Objective

To compare the clinical validity and utility of Likert assessment and the Prostate Imaging Reporting and Data System (PI‐RADS) v2 in the detection of clinically significant and insignificant prostate cancer.

Patients and Methods

A total of 489 pre‐biopsy multiparametric magnetic resonance imaging (mpMRI) scans in consecutive patients were subject to prospective paired reporting using both Likert and PI‐RADS v2 by expert uro‐radiologists. Patients were offered biopsy for any Likert or PI‐RADS score ≥4 or a score of 3 with PSA density ≥0.12 ng/mL/mL. Utility was evaluated in terms of proportion biopsied, and proportion of clinically significant and insignificant cancer detected (both overall and on a ‘per score’ basis). In those patients biopsied, the overall accuracy of each system was assessed by calculating total and partial area under the receiver‐operating characteristic (ROC) curves. The primary threshold of significance was Gleason ≥3 + 4. Secondary thresholds of Gleason ≥4 + 3, Ahmed/UCL1 (Gleason ≥4 + 3 or maximum cancer core length [CCL] ≥6 or total CCL≥6) and Ahmed/UCL2 (Gleason ≥3 + 4 or maximum CCL ≥4 or total CCL ≥6) were also used.

Table 1: Comparison of Likert and Prostate Imaging Reporting and Data System scoring.

Results

The median (interquartile range [IQR]) age was 66 (60–72) years and the median (IQR) prostate‐specific antigen level was 7 (5–10) ng/mL. A similar proportion of men met the biopsy threshold and underwent biopsy in both groups (83.8% [Likert] vs 84.8% [PI‐RADS v2]; P = 0.704). The Likert system predicted more clinically significant cancers than PI‐RADS across all disease thresholds. Rates of insignificant cancers were comparable in each group. ROC analysis of biopsied patients showed that, although both scoring systems performed well as predictors of significant cancer, Likert scoring was superior to PI‐RADS v2, exhibiting higher total and partial areas under the ROC curve.

Conclusions

Both scoring systems demonstrated good diagnostic performance, with similar rates of decision to biopsy. Overall, Likert was superior by all definitions of clinically significant prostate cancer. It has the advantages of being flexible, intuitive and allowing inclusion of clinical data. However, its use should only be considered once radiologists have developed sufficient experience in reporting prostate mpMRI.

Read more Articles of the week

Editorial: Does prostate MRI reporting system affect performance of MRI in men with a clinical suspicion of PCa?

Magnetic Resonance Imaging (MRI) of prostate continues to transform the way prostate cancer is being diagnosed and risk stratified. Multiple prospective single (e.g. the Biparametric MRI for Detection of Prostate Cancer [BIDOC] [1] and Improved Prostate Cancer Diagnosis ‐ Combination of Magnetic Resonance Imaging and Biomarkers [IMPROD] [2]) and multi‐institution trials (e.g. PROstate MRI Imaging Study [PROMIS] [3], PRostate Evaluation for Clinically Important Disease: Sampling Using Image‐guidance Or Not? [PRECISION] [4], multi‐institutional IMPROD (Multi‐IMPROD) [5], Assessment of Prostate MRI Before Prostate Biopsies [MRI‐FIRST] [6]) have demonstrated the potential of prostate MRI to limit the number of unnecessary biopsies in men with suspected prostate cancer.

In this issue of the BJUI, Khoo et al. [7] retrospectively analysed reports from a multicentre prostate cancer pathway registry, Rapid Assessment and Prostate Imaging for Diagnosis (RAPID). Men with a clinical suspicion of prostate cancer were enrolled based on various clinical criteria such as: age, performance status, and PSA level. All men had a pre‐biopsy MRI, including dynamic contrast‐enhanced MRI, reported using a 5‐point Likert scale and Prostate Imaging Reporting and Data System version 2.0 (PI‐RADSv2.0) systems by one of four uro‐radiologists (5–9 years of experience of prostate multi‐parametric MRI). Subsequently, all Likert and PI‐RADSv2.0 scores were reviewed by a dedicated reader in a multidisciplinary team setting. Likert scores were reported with knowledge of clinical variables such as: PSA, patient age, and past medical history. Men with Likert or PI‐RADSv2.0 score ≥4 or a score of 3 with a PSA density ≥0.12 ng/mL/mL underwent transperineal targeted prostate biopsies. Additionally, some men below these thresholds deemed to be at particularly high risk of prostate cancer (usually based on presence of other risk factors such as family history, high PSA kinetics or ethnic risk) were also offered biopsy on a case‐by‐case basis. At least three targeted cores were taken from each MRI‐suspicious lesion and no systematic biopsy cores were included in this analysis.

In total, 489 men were included in the analyses, with 377 and 408 men meeting the Likert and PI‐RADSv2.0 biopsy thresholds, respectively, of whom 316 (83.8%) and 346 (84.8%) proceeded to biopsy (P = 0.704), respectively. The Likert system predicted more clinically significant prostate cancer than PI‐RADSv2.0, e.g., 58.2% (184/316) vs 53.2% (184/346) of prostate cancer (P = 0.190) with Gleason score ≥3+4. Detection rates of clinically insignificant prostate cancer were comparable. The authors concluded that the Likert system was superior to PI‐RADSv2.0.

The authors should be congratulated on their effort to improve prostate MRI as a risk‐stratification and biopsy targeting tool. However, caution should be applied when translating these results to other centres. In order to access inter‐centre variability and to allow independent external validation, research groups should provide access to their imaging and patient level data. The authors do not provide such access and do not present inter‐reader variability of Likert vs PI‐RADv2.0 for all enrolled men. Similar to other trials evaluating prostate MRI in men with a clinical suspicion of prostate cancer, true prostate cancer and significant prostate cancer prevalence in this cohort is unknown, as men did not undergo saturation biopsy or prostatectomy with whole‐mount prostatectomy sections.

Overall, this retrospective analysis by Khoo et al. [7], comparing Likert scores reported using clinical variables vs PIRADSv2.0, provides further evidence that good quality prostate MRI can be used as a risk‐stratification and biopsy targeting tool in men with a clinical suspicion of prostate cancer. Each centre needs to develop its own quality control process and continually review its own performance measures of prostate MRI and MRI‐targeted biopsy. Furthermore, in order to access inter‐centre variability in performance of prostate MRI and MRI‐targeted biopsy, free public access to imaging and patient level data should be provided.

by Ivan Jambor and Ugo Falagorio

References

  1. Boesen LNørgaard NLogager V et al. Assessment of the diagnostic accuracy of biparametric magnetic resonance imaging for prostate cancer in biopsy‐naive men: the Biparametric MRI for Detection of Prostate Cancer (BIDOC) study. JAMA Netw Open 201811– 28
  2. Jambor IBoström PJTaimen P et al. Novel biparametric MRI and targeted biopsy improves risk stratification in men with a clinical suspicion of prostate cancer (IMPROD Trial). J Magn Reson Imaging 2017461089– 95
  3. Ahmed HUEl‐Shater Bosaily ABrown LC et al. Diagnostic accuracy of multi‐parametric MRI and TRUS Biopsy in prostate cancer (PROMIS): a paired validating confirmatory  study. Lancet 2017389815– 22
  4. Kasivisvanathan VRannikko ASBorghi M et al. MRI‐targeted or standard biopsy for prostate‐cancer diagnosis. N Engl J Med 20183781767– 77
  5. Jambor IVerho JEttala O et al. Validation of IMPROD biparametric MRI in men with clinically suspected prostate cancer: A prospective multi‐institutional trial. PLoS Med 201916: e1002813.
  6. Rouvière OPuech PRenard‐Penna R et al. Use of prostate systematic and targeted biopsy on the basis of multiparametric MRI in biopsy‐naive patients (MRI‐FIRST): a prospective, multicentre, paired diagnostic study. Lancet Oncol 201920100– 9
  7. Khoo CCEldred‐Evans DPeters M et al. Likert vs PI‐RADS v2: a comparison of two radiological scoring systems for detection of clinically significant prostate cancer. BJU Int 2019; 125:49-55.

 

Video: Likert vs PI-RADS v2

Likert vs PI‐RADS v2: a comparison of two radiological scoring systems for detection of clinically significant prostate cancer

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Abstract

Objective

To compare the clinical validity and utility of Likert assessment and the Prostate Imaging Reporting and Data System (PI‐RADS) v2 in the detection of clinically significant and insignificant prostate cancer.

Patients and Methods

A total of 489 pre‐biopsy multiparametric magnetic resonance imaging (mpMRI) scans in consecutive patients were subject to prospective paired reporting using both Likert and PI‐RADS v2 by expert uro‐radiologists. Patients were offered biopsy for any Likert or PI‐RADS score ≥4 or a score of 3 with PSA density ≥0.12 ng/mL/mL. Utility was evaluated in terms of proportion biopsied, and proportion of clinically significant and insignificant cancer detected (both overall and on a ‘per score’ basis). In those patients biopsied, the overall accuracy of each system was assessed by calculating total and partial area under the receiver‐operating characteristic (ROC) curves. The primary threshold of significance was Gleason ≥3 + 4. Secondary thresholds of Gleason ≥4 + 3, Ahmed/UCL1 (Gleason ≥4 + 3 or maximum cancer core length [CCL] ≥6 or total CCL≥6) and Ahmed/UCL2 (Gleason ≥3 + 4 or maximum CCL ≥4 or total CCL ≥6) were also used.

Results

The median (interquartile range [IQR]) age was 66 (60–72) years and the median (IQR) prostate‐specific antigen level was 7 (5–10) ng/mL. A similar proportion of men met the biopsy threshold and underwent biopsy in both groups (83.8% [Likert] vs 84.8% [PI‐RADS v2]; P = 0.704). The Likert system predicted more clinically significant cancers than PI‐RADS across all disease thresholds. Rates of insignificant cancers were comparable in each group. ROC analysis of biopsied patients showed that, although both scoring systems performed well as predictors of significant cancer, Likert scoring was superior to PI‐RADS v2, exhibiting higher total and partial areas under the ROC curve.

Conclusions

Both scoring systems demonstrated good diagnostic performance, with similar rates of decision to biopsy. Overall, Likert was superior by all definitions of clinically significant prostate cancer. It has the advantages of being flexible, intuitive and allowing inclusion of clinical data. However, its use should only be considered once radiologists have developed sufficient experience in reporting prostate mpMRI.

 

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Article of the month: Exercise‐induced attenuation of treatment side‐effects in patients with newly diagnosed PCa beginning androgen‐deprivation therapy: a randomised controlled trial

Every month, the Editor-in-Chief selects an Article of the Month from the current issue of BJUI. The abstract is reproduced below and you can click on the button to read the full article, which is freely available to all readers for at least 30 days from the time of this post.

In addition to the article itself, there is an editorial written by a prominent member of the urology community, a video prepared by the authors and a visual abstract providing a graphical representation of the article; we invite you to use the comment tools at the bottom of each post to join the conversation. 

If you only have time to read one article this week, we recommend this one.

Exercise‐induced attenuation of treatment side‐effects in patients with newly diagnosed prostate cancer beginning androgen‐deprivation therapy: a randomised controlled trial

Wilphard Ndjavera*, Samuel T. Orange, Alasdair F. O’Doherty, Anthony S. Leicht, Mark Rochester*, Robert Mills* and John M. Saxton†§

*Department of Urology, Norfolk and Norwich University Hospital, Norwich, UK, Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK, Sport and Exercise Science, College of Healthcare Sciences, James Cook University, Townsville, QLD, Australia and §Norwich Medical School, Faculty of Medicine and Health Sciences, Norwich Research Park, University of East Anglia, Norwich, UK

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Abstract

Objectives

(i) To assess whether exercise training attenuates the adverse effects of treatment in patients with newly diagnosed prostate cancer beginning androgen‐deprivation therapy (ADT), and (ii) to examine whether exercise‐induced improvements are sustained after the withdrawal of supervised exercise.

Patients and Methods

In all, 50 patients with prostate cancer scheduled for ADT were randomised to an exercise group (n = 24) or a control group (n = 26). The exercise group completed 3 months of supervised aerobic and resistance exercise training (twice a week for 60 min), followed by 3 months of self‐directed exercise. Outcomes were assessed at baseline, 3‐ and 6‐months. The primary outcome was difference in fat mass at 3‐months. Secondary outcomes included: fat‐free mass, cardiopulmonary exercise testing variables, QRISK®2 (ClinRisk Ltd, Leeds, UK) score, anthropometry, blood‐borne biomarkers, fatigue, and quality of life (QoL).

Table 2 Outcomes at baseline, 3- and 6-months.

Results

At 3‐months, exercise training prevented adverse changes in peak O2 uptake (1.9 mL/kg/min, P = 0.038), ventilatory threshold (1.7 mL/kg/min, P = 0.013), O2 uptake efficiency slope (0.21, P = 0.005), and fatigue (between‐group difference in Functional Assessment of Chronic Illness Therapy‐Fatigue score of 4.5 points, P = 0.024) compared with controls. After the supervised exercise was withdrawn, the differences in cardiopulmonary fitness and fatigue were not sustained, but the exercise group showed significantly better QoL (Functional Assessment of Cancer Therapy‐Prostate difference of 8.5 points, P = 0.034) and a reduced QRISK2 score (−2.9%, P = 0.041) compared to controls.

Conclusion

A short‐term programme of supervised exercise in patients with prostate cancer beginning ADT results in sustained improvements in QoL and cardiovascular events risk profile.

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Editorial: The benefits of regular exercise

January is the month when we wish each other happiness and success for the year ahead. It is also the month when many are recovering from the excesses of the festive season. This is the time when gyms and diets become popular again with offers of reduced rates to attract customers. For Londoners the spring marathon is not far away and you often see runners training in different parks despite the cold weather and icy routes.

If you think this year is the one where you are about to start going to the gym, then we recommend you the best shake for post workout to add extra point to your routine.

Is this just a temporary fad? Or is there truly some benefit to be had by exercising regularly?

Over the past few years, we have published several papers showing clear associations between metabolic syndrome and LUTS, and the benefits of preoperative optimisation with diet and exercise prior to major urological surgery. In this issue of the BJUI, we present a small but well‐designed randomised controlled trial on the benefits of exercise in attenuating the treatment side‐effects in patients with newly diagnosed prostate cancer starting on androgen‐deprivation therapy [1]. It is an example of collaborative working between Urologists and experts on Sport, Exercise and Rehabilitation therapy. The authors clearly demonstrate that a short‐term programme of supervised exercise results in improvements in quality of life and cardiovascular risk profile in patients on hormonal therapy. Even after the supervised exercise was withdrawn and followed by self‐directed exercise, the benefits continued as compared to the control group.

As Urologists, we can help our patients in this journey by adopting a more active lifestyle ourselves. Inspired by Fiona Godlee’s article in the BMJ [2], I have started printing it and actually handing it/e‐mailing it to my patients. The paper describes physical activity as ‘The miracle cure’ with very few side‐effects. Any level of activity is better than none and a gentle start usually avoids an unexpected injury.

There is no better time to lead by example this New Year!

by Prokar Dasgupta

References

  1. Ndjevera WOrange STO’Doherty AF et al. Exercise‐induced attenuation of treatment side‐effects in patients with newly diagnosed prostate cancer beginning androgen‐deprivation therapy: a randomised controlled trial. BJU Int 2019: 125; 28-37.
  2. Godlee FThe miracle cureBMJ 2019366l5605.
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