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The role of surgery in high-risk localised prostate cancer

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CPD Review and Questions

Keywords: high-risk prostate cancer, radical prostatectomy, radical radiotherapy
Authors: Vincent J. Gnanapragasam, Malcolm D. Mason, Greg L. Shaw, David E. Neal
Corresponding Author: Vincent J. Gnanapragasam

Learning Objectives

After reading this paper you will be able to:

  1. To understand the incidence and classification of high risk localised prostate cancer
  2. To understand the current data on outcomes from surgery and radiotherapy for this group of patients and the role of multimodal therapy.
  3. To understand the issues and controversies in deciding optimal management for these patients and the critical need for a comparative trial.

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BJUI Website Editor, Dr Marcus Drake interviews Vincent J. Gnanapragasam MD on The role of surgery in high-risk localised prostate cancer

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The male sling for post-prostatectomy urinary incontinence: a review of contemporary sling designs and outcomes

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CPD Review and Questions

Keywords: male slings, urinary incontinence, post-prostatectomy incontinence
Authors: Daniel J. Lee, Eugene K. Cha, Justin M. Dubin, Himisha Beltran, Thomas F. Chromecki, Harun Fajkovic, Douglas S. Scherr, Scott T. Tagawa, Shahrokh F. Shariat

Learning Objectives

After reading this paper you will be able to:

  1. Describe the three principle slings described in the literature
  2. Summarise the evidence for efficacy of each sling and their associated adverse events
  3. Describe the quality of the evidence base (eg study design) underlying the use of slings
  4. Identify patient groups for which a particular sling may be suitable or unsuitable
  5. Summarise the advantages of slings compared with the artificial urinary sphincter

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Novel therapeutics for the management of castration-resistant prostate cancer (CRPC)

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CPD Review

Keywords: castration-resistant prostate cancer, prostate-specific antigen, docetaxel, cytotoxic agents, first-line therapy, second-line therapy
Authors: Daniel J. Lee, Eugene K. Cha, Justin M. Dubin, Himisha Beltran, Thomas F. Chromecki, Harun Fajkovic, Douglas S. Scherr, Scott T. Tagawa, Shahrokh F. Shariat

Learning Objectives

After reading this paper you will be able to:

  1. Summarise the advantages and disadvantages of biomarkers in the management of CRPC
  2. Describe the evidence for new therapeutic combinations with docetaxel and new cytotoxic agents in the treatment of CRPC
  3. Identify novel therapeutic targets and summarise the evidence for their use in the treatment of CRPC
  4. Summarise the evidence supporting the role of bisphosphonates and radionuclides in the treatment of bone metastases in men with CRPC

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You can read the Paper here
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