Abstract Objective To assess the differential response to neoadjuvant chemotherapy (NAC) in patients with UCB compared to UTUC treated with radical surgery. Materials and methods Data from 1299 patients with UCB and 276 with UTUC were obtained from multicentric collaborations. The association of disease location (UCB vs UTUC) with pathologic complete response (pCR; defined as […]
Abstract Objective To assess the differential response to neoadjuvant chemotherapy (NAC) in patients with UCB compared to UTUC treated with radical surgery. Materials and methods Data from 1299 patients with UCB and 276 with UTUC were obtained from multicentric collaborations. The association of disease location (UCB vs UTUC) with pathologic complete response (pCR; defined as […]
Abstract Purpose To investigate the impact of 68Gallium prostate‐specific membrane antigen (68Ga‐PSMA) tracers on the management of prostate cancer patients with biochemical recurrence (BCR) by systematical review and meta‐analysis. Materials and Methods We performed a literature search on PubMed, Embase, and Web of Science databases up to October 29, 2019. We included studies that reported […]
Objectives To assess whether free PSA ratio (FPSAR) at biochemical recurrence (BCR) can predict metastasis, castrate‐resistant prostate cancer (CRPC), and cancer‐specific survival (CSS), following therapy for localised disease. Patients and Methods A single‐centre retrospective cohort study (NCT03927287) including a discovery cohort composed of patients with an FPSAR after radical prostatectomy (RP) or radiotherapy (RT) between […]
Objectives To assess whether free PSA ratio (FPSAR) at biochemical recurrence (BCR) can predict metastasis, castrate‐resistant prostate cancer (CRPC), and cancer‐specific survival (CSS), following therapy for localised disease. Patients and Methods A single‐centre retrospective cohort study (NCT03927287) including a discovery cohort composed of patients with an FPSAR after radical prostatectomy (RP) or radiotherapy (RT) between […]
Objectives To present historical and contemporary hypotheses on the pathogenesis of benign prostatic hyperplasia (BPH), and the potential implications for current medical therapies. Methods The literature on BPH was reviewed. BPH is a prevalent disease with significant health and economic impacts on patients and health organisations across the world, whilst the cause/initiation of the disease […]
Objectives To present historical and contemporary hypotheses on the pathogenesis of benign prostatic hyperplasia (BPH), and the potential implications for current medical therapies. Methods The literature on BPH was reviewed. BPH is a prevalent disease with significant health and economic impacts on patients and health organisations across the world, whilst the cause/initiation of the disease […]
Abstract Objectives To determine the clinical utility of blood tests as a screening tool for metabolic abnormalities in patients with kidney stone disease. Subjects and Methods: Clinical and biochemical data from 709 patients attending the Oxford University Hospitals NHS Foundation Trust for assessment and treatment of kidney stones was prospectively collected between April 2011 and […]
Objectives To assess the role of the angiotensin receptor blocker losartan on the recoverability of renal function after de‐obstruction in patients with anuria and oliguria. Materials and Methods This was a double‐blind randomized placebo‐controlled trial in anuric or oliguric patients with calcular obstruction of solitary kidney. Patients with an anomalous kidney or those with an […]
Abstract Objectives To investigate the therapy of stress urinary incontinence in a preclinical setting, cells were injected by William’s needle in the urethrae of minipigs. But the injected cells were frequently misplaced or lost. Thus, we investigated if needle‐free cell injections by a novel waterjet technology facilitate precise injections in the urethral sphincter complex. Materials […]