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About Bryn M. Launer, Kevin T. McVary, William A. Ricke, Granville L. Lloyd

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Entries by Bryn M. Launer, Kevin T. McVary, William A. Ricke, Granville L. Lloyd

The Rising Worldwide Impact of Benign Prostatic Hyperplasia

Abstract The COVID‐19 pandemic has placed unprecedented strain on healthcare systems worldwide with the requirement to treat large influxes of infected patients, many of whom require respiratory support. Healthcare systems have had to redirect resources and redeploy staff away from routine diagnostic, treatment and follow‐up services. The UK’s National Health Service (NHS) is no different […]

Impact of Circulating miRNA‐371a‐3p Test on Appropriateness of Treatment and Cost Outcomes in Patients with Stage I Nonseminomatous Germ Cell Tumors

Abstract The COVID‐19 pandemic has placed unprecedented strain on healthcare systems worldwide with the requirement to treat large influxes of infected patients, many of whom require respiratory support. Healthcare systems have had to redirect resources and redeploy staff away from routine diagnostic, treatment and follow‐up services. The UK’s National Health Service (NHS) is no different […]

Certification in reporting multiparametric MRI of the prostate ‐ recommendations of a UK consensus meeting

Abstract Multiparametric (mp) MRI of the prostate is now recommended as the initial investigation method for men with suspected prostate cancer within both UK and international guidelines. Potential benefits of this pathway include: (a) reductions in the number of men requiring biopsy; (b) reductions in the diagnoses of indolent cancers unlikely to cause harm, minimizing […]

Stereotactic radiotherapy combined with immune‐ or targeted therapy for metastatic renal cell carcinoma

Abstract Multiparametric (mp) MRI of the prostate is now recommended as the initial investigation method for men with suspected prostate cancer within both UK and international guidelines. Potential benefits of this pathway include: (a) reductions in the number of men requiring biopsy; (b) reductions in the diagnoses of indolent cancers unlikely to cause harm, minimizing […]

Negative first follow‐up prostate biopsy on active surveillance is associated with decreased risk of upgrading, suspicion of progression and converting to active treatment

Abstract Objective To determine the risk of disease progression and conversion to active treatment following a negative biopsy while on AS for PCa. Patients and methods Men on the AS programme at a single tertiary hospital (London, UK) between 2003‐2018 with confirmed low‐intermediate risk PCa, Grade Group<3, clinical stage <T3, diagnostic PSA <20ng/mL. This cohort […]

Risk‐adapted biopsy decision based on prostate MRI and PSA‐density for enhanced biopsy avoidance in first prostate cancer diagnostic work‐up

Abstract Prostate MRI has been integrated into the diagnostic work‐up for men at risk of having clinically significant cancer in multiple clinical care guidelines. Owing to the low false‐negative rate of prostate MRI accompanying a sensitivity averaging 91%, we can reduce biopsies (by 30%) and indolent cancer detection, while maintaining (or even improving) detection of […]

The dramatic COVID 19 outbreak in Italy is responsible of a huge drop of urological surgical activity: a multicenter observational study

Objective To describe the trend in surgical volume in urology in Italy during the coronavirus disease 2019 (COVID‐19) outbreak, as a result of the abrupt reorganisation of the Italian national health system to augment care provision to symptomatic patients with COVID‐19. Methods A total of 33 urological units with physicians affiliated to the AGILE consortium […]

Tumor infiltrating immune cells to predict response to intravesical BCG in Patients with Non‐muscle invasive Bladder Cancer: A Systematic Review and meta‐analysis

Abstract Purpose To investigate the predictive value of tumor infiltrating immune cells (TIICs) on oncological outcomes and response to BCG treatment in patients with Non‐muscle invasive bladder cancer (NMIBC). Materials and Methods A systematic review and meta‐analysis was performed using the PubMed, Scopus, and Cochrane Library on July 2020 to identify relevant studies according to […]

Personalized 3D‐printed transparent kidney model for robotic partial nephrectomy in patients with complex renal tumors (RENAL nephrometry score ≥ 7): A prospective case‐matched study

Abstract Objectives To evaluate the effectiveness of a 3D‐printed transparent kidney model as a surgical navigator for robotic partial nephrectomy (RPN) in patients with complex renal tumors defined as RENAL nephrometry scores of ≥ 7. Materials and methods A total of 80 patients who underwent RPNs were included in the current prospective case‐matched study [case […]

Morbidity and mortality after robot‐assisted radical cystectomy with intracorporeal urinary diversion in octogenarians – results from the EAU Robotic Urology Section (ERUS) Scientific Working Group

Objectives To define pre‐morbid, clinical, laboratory, and imaging features and identify prognostic factors associated with morbidity and mortality in patients with emphysematous pyelonephritis (EPN) and develop a prognostic scoring system for improving management outcomes. Patients and Methods From January 2009 to December 2019, we performed a prospective study of all patients with a suspected diagnosis […]

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